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Flow-based samplers represent a promising candidate to successfully mitigate critical slowing down in lattice field theory simulations. In this talk we first review recent developments of this class of generative machine-learning models and the challenges that they face when applied to four-dimensional lattice gauge theories. Then, we analyze the interesting scaling properties that flow-based samplers manifest when combined with out-of-equilibrium simulations based on Jarzynski equality in the so-called Stochastic Normalizing Flows (SNFs) framework. Lastly, a strategy to mitigate topological freezing in the case of the SU(3) pure gauge theory using SNFs is outlined.